HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Cyanopyridine-5-boronic acid pinacol ester → 5-(8-Morpholino-2-((quinolin-2-yloxy)methyl)imidazo[1,2-b]pyridazin-3-yl)picolinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Cyanopyridine-5-boronic acid pinacol ester | HCID 16414188 | — |
| Reactant | 2-((3-Bromo-8-morpholinoimidazo[1,2-b]pyridazin-2-yl)methoxy)quinoline | HCID 117728754 | — |
| Product | 5-(8-Morpholino-2-((quinolin-2-yloxy)methyl)imidazo[1,2-b]pyridazin-3-yl)picolinonitrile | HCID 117728750 | — |
Reaction Steps
Compound 83b was reacted under Suzuki coupling conditions with 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile using the procedures described in Example 1, Step E to afford compound 83c as a white solid. Mass Spectrum (LCMS, ESI pos.) Calcd. For C26H21N7O2: 464.2 (M+H). Found 464.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193736B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-4e363a95299f4cbd870bc94a163ecb7b |
| Source note | uspto-grants-2015_11 |