Carbamate → HCID 178502110, compound

HRID 71881Notes

Reaction equation

[CH3:1][O:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11](=[O:21])[CH:12]([NH:16][C:17]([O:19][CH3:20])=[O:18])[CH:13](C)C)[CH:7]([C:22]2[NH:23][CH:24]=[C:25]([C:27]3[CH:32]=[CH:31][C:30]([C:33]#[C:34][C:35]4[CH:40]=[CH:39][C:38]([C:41]5[NH:42][C:43]([CH:46]6[CH2:50][CH2:49][CH2:48][N:47]6[C:51](=[O:61])[CH:52]([NH:56][C:57]([O:59][CH3:60])=[O:58])[CH:53]([CH3:55])[CH3:54])=[N:44][CH:45]=5)=[CH:37][CH:36]=4)=[CH:29][CH:28]=3)[N:26]=2)[CH2:6]1)=[O:4].N[C@H](C(O)=O)C(C)C.C(=O)([O-])N.N[C@H](C(O)=O)C>>[CH3:1][O:2][C:3]([N:5]1[CH2:10][CH2:9][N:8]([C:11](=[O:21])[CH:12]([NH:16][C:17]([O:19][CH3:20])=[O:18])[CH3:13])[CH:7]([C:22]2[NH:23][CH:24]=[C:25]([C:27]3[CH:28]=[CH:29][C:30]([C:33]#[C:34][C:35]4[CH:40]=[CH:39][C:38]([C:41]5[NH:42][C:43]([CH:46]6[CH2:50][CH2:49][CH2:48][N:47]6[C:51](=[O:61])[CH:52]([NH:56][C:57]([O:59][CH3:60])=[O:58])[CH:53]([CH3:55])[CH3:54])=[N:44][CH:45]=5)=[CH:37][CH:36]=4)=[CH:31][CH:32]=3)[N:26]=2)[CH2:6]1)=[O:4]

Participants

Reactant 4

HCID 276Carbamate2×

HCID 5950L-Alanine

HCID 6287L-Valine

HCID 178502197HCID 178502197, compound

Product 1

HCID 178502110HCID 178502110, compound

Procedure

was prepared in a similar fashion to 4-(2-Methoxycarbonylamino-3-methyl-butyryl)-3-{4-[4-(4-{2-[1-(2-methoxycarbonylamino-3-methyl-butyryl)-pyrrolidin-2-yl]-3H-imidazol-4-yl}-phenylethynyl)-phenyl]-1H-imidazol-2-yl}-piperazine-1-carboxylic acid methyl ester (example DP), replacing the valine derived carbamate with the corresponding alanine derived carbamate.

Sources & evidence

ORD record: ord-fc1f0527e3dc4aac9d5a9c11bf8032db
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08822430B2

Reaction notes

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