HRID71883

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID145742

L-Proline

C5H9NO2

HCID57263372

未命名化合物

结构：COC(=O)NC(C(=O)N1CCCC1c1ncc(-c2ccc3c(c2)C(F)(F)c2cc(-c4ccc5nc(C6C7CCC(C7)N6C(=O)C(NC(=O)OC)C(C)C)[nH]c5c4)ccc2-3)[nH]1)C(C)C

HCID66620162

未命名化合物

PRODUCTS

生成物

结构：COC(=O)NC(C(=O)N1CC(C#N)CC1c1ncc(-c2ccc3c(c2)C(F)(F)c2cc(-c4ccc5nc(C6C7CCC(C7)N6C(=O)C(NC(=O)OC)C(C)C)[nH]c5c4)ccc2-3)[nH]1)C(C)C

HCID66620681

未命名化合物

PROCEDURE

实验过程

was prepared in a similar fashion to (1-{2-[5-(9,9-Difluoro-7-{2-[2-(2-methoxycarbonylamino-3-methyl-butyryl)-2-aza-bicyclo[2.2.1]hept-3-yl]-3H-benzoimidazol-5-yl}-9H-fluoren-2-yl)-1H-imidazol-2-yl]-pyrrolidine-1-carbonyl}-2-methyl-propyl)-carbamic acid methyl ester (Example DK), replacing the proline derivative with the corresponding 4-cyano-proline derivative.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5b576aff3e9d41dbb5bf22e1c542ff87
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08822430B2
来源说明: uspto-grants-2014_09

反应 SMILES

[CH3:1][O:2][C:3](=[O:63])[NH:4][CH:5]([C:9]([N:11]1[CH2:15][CH2:14][CH2:13][CH:12]1[C:16]1[NH:17][C:18]([C:21]2[CH:33]=[CH:32][C:31]3[C:30]4[C:25](=[CH:26][C:27]([C:34]5[CH:60]=[CH:59][C:37]6[N:38]=[C:39]([CH:41]7[CH:46]8[CH2:47][CH:43]([CH2:44][CH2:45]8)[N:42]7[C:48](=[O:58])[CH:49]([NH:53][C:54]([O:56][CH3:57])=[O:55])[CH:50]([CH3:52])[CH3:51])[NH:40][C:36]=6[CH:35]=5)=[CH:28][CH:29]=4)[C:24]([F:62])([F:61])[C:23]=3[CH:22]=2)=[CH:19][N:20]=1)=[O:10])[CH:6]([CH3:8])[CH3:7].[NH:64]1CCC[C@H:65]1C(O)=O.C(C1CN[C@H](C(O)=O)C1)#N>>[CH3:57][O:56][C:54](=[O:55])[NH:53][CH:49]([C:48]([N:42]1[CH:41]([C:39]2[NH:40][C:36]3[CH:35]=[C:34]([C:27]4[CH:28]=[CH:29][C:30]5[C:31]6[C:23](=[CH:22][C:21]([C:18]7[NH:17][C:16]([CH:12]8[CH2:13][CH:14]([C:65]#[N:64])[CH2:15][N:11]8[C:9](=[O:10])[CH:5]([NH:4][C:3]([O:2][CH3:1])=[O:63])[CH:6]([CH3:7])[CH3:8])=[N:20][CH:19]=7)=[CH:33][CH:32]=6)[C:24]([F:62])([F:61])[C:25]=5[CH:26]=4)[CH:60]=[CH:59][C:37]=3[N:38]=2)[CH:46]2[CH2:47][CH:43]1[CH2:44][CH2:45]2)=[O:58])[CH:50]([CH3:52])[CH3:51]