Benzyl isocyanate → ethyl 2-(1-Methyl-2-(benzylcarbamoyl)hydrazinyl)acetate

HRID 718881Notes

Reaction equation

HRID 718881 reaction equation
[CH3:1][N:2]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[NH2:3].[CH2:10]([N:17]=[C:18]=[O:19])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH3:1][N:2]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[NH:3][C:18](=[O:19])[NH:17][CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 76639Benzyl isocyanateHCID 20288078Ethyl 2-(1-methylhydrazinyl)acetate

Product 1

HCID 66977957ethyl 2-(1-Methyl-2-(benzylcarbamoyl)hydrazinyl)acetateYield 76%

Procedure

According to the procedure described in the synthesis method of Compound V-1 with the modification that the reaction was carried out overnight, ethyl 2-(1-methylhydrazinyl)acetate (Compound XV-2) 10 ml (76 mmol) was reacted with benzyl isocyanate 11.1 g (83.3 mmol) to obtain the title compound 15.2 g (76%).

Workup

  1. customdescribed in the synthesis method of Compound V-1 with the modification that the reaction

Sources & evidence

ORD record
ord-d3af802979d0478eac5f9c8d983cf712
Source dataset
uspto-grants-2015_11
Patent number
US09193734B2

Reaction notes

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