2-(2-(Ethylcarbamoyl)-1-methylhydrazinyl)acetic acid → HCID 86698541, compound

HRID 718969Notes

Reaction equation

HRID 718969 reaction equation
[CH2:1]([NH:3][C:4]([NH:6][N:7]([CH2:9][C:10]([OH:12])=O)[CH3:8])=[O:5])[CH3:2].[NH2:13][C@H:14]([C:27]([N:29]([C@@H:41]([CH3:49])[CH:42]([O:46][CH2:47][CH3:48])[O:43][CH2:44][CH3:45])[CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[C:35]2[C:40]=1[N:39]=[CH:38][CH:37]=[CH:36]2)=[O:28])[CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:25])([CH3:24])[CH3:23]>>[CH2:47]([O:46][CH:42]([O:43][CH2:44][CH3:45])[C@@H:41]([N:29]([CH2:30][C:31]1[CH:32]=[CH:33][CH:34]=[C:35]2[C:40]=1[N:39]=[CH:38][CH:37]=[CH:36]2)[C:27](=[O:28])[C@@H:14]([NH:13][C:10](=[O:12])[CH2:9][N:7]([CH3:8])[NH:6][C:4](=[O:5])[NH:3][CH2:1][CH3:2])[CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20](=[O:26])[O:21][C:22]([CH3:24])([CH3:25])[CH3:23])[CH3:49])[CH3:48]

Participants

3

Reactant 2

HCID 533974172-(2-(Ethylcarbamoyl)-1-methylhydrazinyl)acetic acidHCID 86698540HCID 86698540, compound

Product 1

HCID 86698541HCID 86698541, compound

Procedure

According to the procedure described in the synthesis method of Compound II-15, 2-(2-(ethylcarbamoyl)-1-methylhydrazinyl)acetic acid (Compound VI-9) 51 mg (0.29 mmol) was coupled with tert-butyl (S)-5-amino-6-(((S)-1,1-diethoxypropan-2-yl)(quinolin-8-ylmethyl)amino)-6-oxohexylcarbamate (Compound IV-14) 100 mg (0.19 mmol) to obtain the title compound.

Sources & evidence

ORD record
ord-399192f4bd174e21aa775328343ca6b0
Source dataset
uspto-grants-2015_11
Patent number
US09193734B2

Reaction notes

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