2-(2-((4-Chlorobenzyl)carbamoyl)-1-methylhydrazinyl)acetic acid → (S)-tert-butyl 3-(2-(2-(4-chlorobenzylcarbamoyl)-1-methylhydrazinyl)acet-amido)-4-(((S)-1,1-diethoxypropan-2-yl)(quinolin-8-ylmethyl)amino)-4-oxobutanoate

Participants

Role	Name	HCID	Charge
Reactant	2-(2-((4-Chlorobenzyl)carbamoyl)-1-methylhydrazinyl)acetic acid	HCID 53397501	—
Reactant	(S)-tert-butyl 3-amino-4-(((S)-1,1-diethoxypropan-2-yl)(quinolin-8-ylmethyl)amino)-4-oxobutanoate	HCID 67075453	—
Product	(S)-tert-butyl 3-(2-(2-(4-chlorobenzylcarbamoyl)-1-methylhydrazinyl)acet-amido)-4-(((S)-1,1-diethoxypropan-2-yl)(quinolin-8-ylmethyl)amino)-4-oxobutanoate	HCID 86698542	—

Reaction Steps

According to the procedure described in the synthesis method of Compound II-15, 2-(2-(4-chlorobenzylcarbamoyl)-1-methylhydrazinyl)acetic acid (Compound VI-7) 89 mg (0.33 mmol) was coupled with (S)-tert-butyl 3-amino-4-(((S)-1,1-diethoxypropan-2-yl)-(quinolin-8-ylmethyl)amino)-4-oxobutanoate (Compound IV-17) 100 mg (0.22 mmol) to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09193734B2
Source dataset	uspto-grants-2015_11
ORD ID	ord-bd28000dee4643c8a0cddd26b8026382
Source note	uspto-grants-2015_11