HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(2-(Benzylcarbamoyl)-1-methylhydrazinyl)acetic acid → (S)-tert-butyl 4-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-3-(2-(2-(benzylcarbamoyl)-1-methylhydrazinyl)acetamido)-4-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(2-(Benzylcarbamoyl)-1-methylhydrazinyl)acetic acid | HCID 53397489 | — |
| Reactant | (S)-tert-butyl 3-amino-4-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-4-oxobutanoate | HCID 67075220 | — |
| Product | (S)-tert-butyl 4-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-3-(2-(2-(benzylcarbamoyl)-1-methylhydrazinyl)acetamido)-4-oxobutanoate | HCID 67088269 | — |
Reaction Steps
According to the procedure described in the synthesis method of Compound II-15, 2-(2-(benzylcarbamoyl)-1-methylhydrazinyl)acetic acid (Compound VI-3) 77 mg (0.32 mmol) was coupled with (S)-tert-butyl 3-amino-4-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-4-oxobutanoate (Compound IV-18) 100 mg (0.22 mmol) to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193734B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-dbd2ff9188bb4406b041bbcdc9dac64e |
| Source note | uspto-grants-2015_11 |