HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(3-(4-Chlorobenzyl)ureidooxy)acetic acid → 1-(4-chlorobenzyl)-3-(2-((S)-1-(((S)-1,1-diethoxypropan-2-yl)(naphthalen-1-ylmethyl)amino)-1-oxopropan-2-ylamino)-2-oxoethoxy)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(3-(4-Chlorobenzyl)ureidooxy)acetic acid | HCID 53397500 | — |
| Reactant | (S)-2-amino-N-((S)-1,1-diethoxypropan-2-yl)-N-(naphthalen-1-ylmethyl)-propanamide | HCID 67075246 | — |
| Product | 1-(4-chlorobenzyl)-3-(2-((S)-1-(((S)-1,1-diethoxypropan-2-yl)(naphthalen-1-ylmethyl)amino)-1-oxopropan-2-ylamino)-2-oxoethoxy)urea | HCID 86652591 | — |
Reaction Steps
According to the procedure described in the synthesis method of Compound II-15, 2-(3-(4-chlorobenzyl)ureidooxy)acetic acid (Compound VI-11) 108 mg (0.42 mmol) was coupled with (S)-2-amino-N—((S)-1,1-diethoxypropan-2-yl)-N-(naphthalen-1-ylmethyl)-propanamide (Compound IV-10) 100 mg (0.28 mmol) to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193734B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-1ed758a1566e44ac9c5cda8f52b9ec5a |
| Source note | uspto-grants-2015_11 |