2-(3-Ethylureidooxy)acetic acid → HCID 86698547, compound

HRID 719013Notes

Reaction equation

[CH2:1]([NH:3][C:4](=[O:11])[NH:5][O:6][CH2:7][C:8]([OH:10])=O)[CH3:2].[NH2:12][C@H:13]([C:26]([N:28]([C@@H:40]([CH3:48])[CH:41]([O:45][CH2:46][CH3:47])[O:42][CH2:43][CH3:44])[CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[C:34]2[C:39]=1[N:38]=[CH:37][CH:36]=[CH:35]2)=[O:27])[CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:24])([CH3:23])[CH3:22]>>[CH2:46]([O:45][CH:41]([O:42][CH2:43][CH3:44])[C@@H:40]([N:28]([CH2:29][C:30]1[CH:31]=[CH:32][CH:33]=[C:34]2[C:39]=1[N:38]=[CH:37][CH:36]=[CH:35]2)[C:26]([C@H:13]([CH2:14][CH2:15][CH2:16][CH2:17][NH:18][C:19](=[O:25])[O:20][C:21]([CH3:23])([CH3:24])[CH3:22])[NH:12][C:8](=[O:10])[CH2:7][O:6][NH:5][C:4](=[O:11])[NH:3][CH2:1][CH3:2])=[O:27])[CH3:48])[CH3:47]

Participants

Reactant 2

HCID 533974162-(3-Ethylureidooxy)acetic acid

HCID 86698540HCID 86698540, compound

Product 1

HCID 86698547HCID 86698547, compound

Procedure

According to the procedure described in the synthesis method of Compound II-15, 2-(3-ethylureidooxy)acetic acid (Compound VI-13) 47 mg (0.29 mmol) was coupled with tert-butyl (S)-5-amino-6-(((S)-1,1-diethoxypropan-2-yl)(quinolin-8-ylmethyl)amino)-6-oxohexylcarbamate (Compound IV-14) 100 mg (0.19 mmol) to obtain the title compound.

Sources & evidence

ORD record: ord-a6971d1d38e64d7aa704703b420fa0a2
Source dataset: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09193734B2

Reaction notes

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