HRID719016

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53397519

未命名化合物

结构：CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@H](C)N

HCID67075261

未命名化合物

PRODUCTS

生成物

结构：CCOC(OCC)[C@H](C)N(Cc1csc2ccccc12)C(=O)[C@H](C)NC(=O)CONC(=O)NCc1ccncc1

HCID86652612

未命名化合物

PROCEDURE

实验过程

According to the procedure described in the synthesis method of Compound II-15, 2-(3-(pyridin-4-ylmethyl)ureidooxy)acetic acid (Compound VI-10) 93 mg (0.41 mmol) was coupled with (S)-2-amino-N-(benzo[b]thiophen-3-ylmethyl)-N—((S)-1,1-diethoxypropan-2-yl)-propanamide (Compound IV-12) 100 mg (0.27 mmol) to obtain the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1c059da121a04377a5671cc52941e0e3
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09193734B2
来源说明: uspto-grants-2015_11

反应 SMILES

[N:1]1[CH:6]=[CH:5][C:4]([CH2:7][NH:8][C:9](=[O:16])[NH:10][O:11][CH2:12][C:13]([OH:15])=O)=[CH:3][CH:2]=1.[NH2:17][C@@H:18]([CH3:41])[C:19]([N:21]([CH2:31][C:32]1[C:33]2[CH:40]=[CH:39][CH:38]=[CH:37][C:34]=2[S:35][CH:36]=1)[C@@H:22]([CH3:30])[CH:23]([O:27][CH2:28][CH3:29])[O:24][CH2:25][CH3:26])=[O:20]>>[S:35]1[CH:36]=[C:32]([CH2:31][N:21]([C@@H:22]([CH3:30])[CH:23]([O:27][CH2:28][CH3:29])[O:24][CH2:25][CH3:26])[C:19](=[O:20])[C@@H:18]([NH:17][C:13](=[O:15])[CH2:12][O:11][NH:10][C:9]([NH:8][CH2:7][C:4]2[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=2)=[O:16])[CH3:41])[C:33]2[CH:40]=[CH:39][CH:38]=[CH:37][C:34]1=2