HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 53397538, compound → 1-(2-((S)-1-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-1-oxopropan-2-ylamino)-2-oxoethoxy)-3-(naphthalen-1-ylmethyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 53397538 | HCID 53397538 | — |
| Reactant | (S)-2-amino-N-(benzo[b]thiophen-3-ylmethyl)-N-((S)-1,1-diethoxypropan-2-yl)propanamide | HCID 67075261 | — |
| Product | 1-(2-((S)-1-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-1-oxopropan-2-ylamino)-2-oxoethoxy)-3-(naphthalen-1-ylmethyl)urea | HCID 86652613 | — |
Reaction Steps
According to the procedure described in the synthesis method of Compound II-15, 2-(3-(naphthalen-1-ylmethyl)ureidooxy)acetic acid (Compound VI-12) 113 mg (0.41 mmol) was coupled with (S)-2-amino-N-(benzo[b]thiophen-3-ylmethyl)-N—((S)-1,1-diethoxypropan-2-yl)propanamide (Compound IV-12) 100 mg (0.27 mmol) to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193734B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-83b7a4c0d25f4db49b204a2c3873128f |
| Source note | uspto-grants-2015_11 |