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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 719017Generated: October 25, 2026

HCID 53397538, compound → 1-(2-((S)-1-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-1-oxopropan-2-ylamino)-2-oxoethoxy)-3-(naphthalen-1-ylmethyl)urea

https://huagongshe.com/reaction/719017

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHCID 53397538HCID 53397538—
Reactant(S)-2-amino-N-(benzo[b]thiophen-3-ylmethyl)-N-((S)-1,1-diethoxypropan-2-yl)propanamideHCID 67075261—
Product1-(2-((S)-1-((benzo[b]thiophen-3-ylmethyl)((S)-1,1-diethoxypropan-2-yl)amino)-1-oxopropan-2-ylamino)-2-oxoethoxy)-3-(naphthalen-1-ylmethyl)ureaHCID 86652613—

Reaction Steps

According to the procedure described in the synthesis method of Compound II-15, 2-(3-(naphthalen-1-ylmethyl)ureidooxy)acetic acid (Compound VI-12) 113 mg (0.41 mmol) was coupled with (S)-2-amino-N-(benzo[b]thiophen-3-ylmethyl)-N—((S)-1,1-diethoxypropan-2-yl)propanamide (Compound IV-12) 100 mg (0.27 mmol) to obtain the title compound.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09193734B2
Source datasetuspto-grants-2015_11
ORD IDord-83b7a4c0d25f4db49b204a2c3873128f
Source noteuspto-grants-2015_11