2-(3-Ethylureidooxy)acetic acid → HCID 67088737, compound

HRID 719029Notes

Reaction equation

HRID 719029 reaction equation
[CH2:1]([NH:3][C:4](=[O:11])[NH:5]OCC(O)=O)[CH3:2].[NH2:12][C@@H:13]([CH2:37][CH:38]1[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1)[C:14]([N:16]([C@@H:28]([CH3:36])[CH:29]([O:33][CH2:34][CH3:35])[O:30][CH2:31][CH3:32])[CH2:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][CH:19]=1)=[O:15]>>[CH:38]1([CH2:37][C@H:13]([NH:12][C:29](=[O:30])[CH2:28][N:16]([CH3:14])[NH:5][C:4]([NH:3][CH2:1][CH3:2])=[O:11])[C:14]([N:16]([C@@H:28]([CH3:36])[CH:29]([O:33][CH2:34][CH3:35])[O:30][CH2:31][CH3:32])[CH2:17][C:18]2[C:27]3[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH:21]=[CH:20][CH:19]=2)=[O:15])[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]1

Participants

3

Reactant 2

HCID 533974162-(3-Ethylureidooxy)acetic acidHCID 67088356HCID 67088356, compound

Product 1

HCID 67088737HCID 67088737, compoundYield 44.6%

Procedure

According to the procedure described in the synthesis method of Compound II-130, 2-(3-ethylureidooxy)acetic acid (Compound VI-13) 32 mg (0.18 mmol) was coupled with (S)-2-amino-3-cyclohexyl-N—((S)-1,1-diethoxypropan-2-yl)-N-(naphthalen-1-ylmethyl)propanamide (Compound IV-23) 66 mg (0.15 mmol) to obtain the title compound 20 mg (23%).

Sources & evidence

ORD record
ord-3186fabe3d4b4fc0b89cdbc12907f103
Source dataset
uspto-grants-2015_11
Patent number
US09193734B2

Reaction notes

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