HCID 21896881, compound → HCID 178467015, compound

HRID 719130Notes

Reaction equation

HRID 719130 reaction equation
ClC1C=CC(C(N)C(C2CCCCC2)N)=CC=1.Cl.C(OC1C=C(OC)C=CC=1C(=N)OCC)C.[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([CH:42]2[NH:46][C:45]([C:47]3[CH:52]=[CH:51][C:50]([O:53][CH3:54])=[CH:49][C:48]=3[O:55][CH2:56][CH3:57])=[N:44][CH:43]2[CH2:58][CH:59]2[CH2:63][CH2:62][CH2:61][CH2:60]2)=[CH:38][CH:37]=1>>[Cl:35][C:36]1[CH:41]=[CH:40][C:39]([CH:42]2[NH:46][C:45]([C:47]3[CH:52]=[CH:51][C:50]([O:53][CH3:54])=[CH:49][C:48]=3[O:55][CH2:56][CH3:57])=[N:44][CH:43]2[CH:58]2[CH2:59][CH2:63][CH2:62][CH2:61][CH2:60]2)=[CH:38][CH:37]=1

Participants

4

Reactant 3

HCID 21896881HCID 21896881, compoundHCID 21896882HCID 21896882, compoundHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 178467015HCID 178467015, compound

Procedure

5-(4-Chloro-phenyl)-4-cyclohexyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-2-cyclohexyl-ethane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 413.1993, calculated for C24H30N2O2Cl [(M+H)+]413.1991.

Sources & evidence

ORD record
ord-f9dc03c00aab42d6bcc49b57fa0fee38
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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