HCID 21896882, compound → HCID 178442280, compound

HRID 719131Notes

Reaction equation

HRID 719131 reaction equation
ClC1C=CC(C(N)C(N)CCCCC)=CC=1.Cl.C(OC1C=C(OC)C=CC=1C(=N)OCC)C.[Cl:34][C:35]1[CH:40]=[CH:39][C:38]([CH:41]2[NH:45][C:44]([C:46]3[CH:51]=[CH:50][C:49]([O:52][CH3:53])=[CH:48][C:47]=3[O:54][CH2:55][CH3:56])=[N:43][CH:42]2[CH2:57][CH:58]2C[CH2:61][CH2:60][CH2:59]2)=[CH:37][CH:36]=1>>[Cl:34][C:35]1[CH:36]=[CH:37][C:38]([CH:41]2[NH:45][C:44]([C:46]3[CH:51]=[CH:50][C:49]([O:52][CH3:53])=[CH:48][C:47]=3[O:54][CH2:55][CH3:56])=[N:43][CH:42]2[CH2:57][CH2:58][CH2:59][CH2:60][CH3:61])=[CH:39][CH:40]=1

Participants

4

Reactant 3

HCID 21896882HCID 21896882, compoundHCID 21896901HCID 21896901, compoundHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 178442280HCID 178442280, compound

Procedure

5-(4-Chloro-phenyl)-2-(2-ethoxy-4-methoxy-phenyl)-4-pentyl-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-heptane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 401.1993, calculated for C23H30N2O2Cl [(M+H)+]401.1991.

Sources & evidence

ORD record
ord-d5d804849698452fa90d138b48ed0efa
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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