HCID 21896882, compound → 4-Butyl-5-(4-chloro-phenyl)-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

HRID 719132Notes

Reaction equation

HRID 719132 reaction equation
ClC1C=CC(C(N)C(N)CCCC)=CC=1.Cl.C(OC1C=C(OC)C=CC=1C(=N)OCC)C.[Cl:33][C:34]1[CH:39]=[CH:38][C:37]([CH:40]2[NH:44][C:43]([C:45]3[CH:50]=[CH:49][C:48]([O:51][CH3:52])=[CH:47][C:46]=3[O:53][CH2:54][CH3:55])=[N:42][CH:41]2[CH2:56][CH:57]2CC[CH2:59][CH2:58]2)=[CH:36][CH:35]=1>>[CH2:56]([CH:41]1[CH:40]([C:37]2[CH:36]=[CH:35][C:34]([Cl:33])=[CH:39][CH:38]=2)[NH:44][C:43]([C:45]2[CH:50]=[CH:49][C:48]([O:51][CH3:52])=[CH:47][C:46]=2[O:53][CH2:54][CH3:55])=[N:42]1)[CH2:57][CH2:58][CH3:59]

Participants

4

Reactant 3

HCID 21896882HCID 21896882, compoundHCID 218968921-(4-Chloro-phenyl)-hexane-1,2-diamineHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 1784415884-Butyl-5-(4-chloro-phenyl)-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Procedure

4-Butyl-5-(4-chloro-phenyl)-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-hexane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 387.1839, calculated for C22H28N2O2Cl [(M+H)+]387.1834.

Sources & evidence

ORD record
ord-360860c42f1e458fadd1fd27219908b3
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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