HCID 21896882, compound → HCID 178467017, compound

HRID 719133Notes

Reaction equation

HRID 719133 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH2:18])[CH:9]([NH2:17])[CH2:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.Cl.[CH2:20]([O:22][C:23]1[CH:33]=[C:32]([O:34][CH3:35])[CH:31]=[CH:30][C:24]=1[C:25](=N)OCC)[CH3:21].ClC1C=CC(C2NC(C3C=CC(OC)=CC=3OCC)=NC2CC2CCCC2)=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[NH:18][C:25]([C:24]3[CH:30]=[CH:31][C:32]([O:34][CH3:35])=[CH:33][C:23]=3[O:22][CH2:20][CH3:21])=[N:17][CH:9]2[CH2:10][CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 21896882HCID 21896882, compoundHCID 21896885HCID 21896885, compoundHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 178467017HCID 178467017, compound

Procedure

5-(4-Chloro-phenyl)-4-cyclohexylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-3-cyclohexyl-propane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 427.2150, calculated for C25H32N2O2Cl [(M+H)+]427.2147.

Sources & evidence

ORD record
ord-a1479262e5ce4c4881b6fb5e11baac44
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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