HCID 21896882, compound → HCID 178467023, compound

HRID 719134Notes

Reaction equation

HRID 719134 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH2:16])[CH:9]([NH2:15])[CH2:10][CH2:11][CH:12]([CH3:14])[CH3:13])=[CH:4][CH:3]=1.Cl.[CH2:18]([O:20][C:21]1[CH:31]=[C:30]([O:32][CH3:33])[CH:29]=[CH:28][C:22]=1[C:23](=N)OCC)[CH3:19].ClC1C=CC(C2NC(C3C=CC(OC)=CC=3OCC)=NC2CC2CCCC2)=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[NH:16][C:23]([C:22]3[CH:28]=[CH:29][C:30]([O:32][CH3:33])=[CH:31][C:21]=3[O:20][CH2:18][CH3:19])=[N:15][CH:9]2[CH2:10][CH2:11][CH:12]([CH3:13])[CH3:14])=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 21896882HCID 21896882, compoundHCID 21896895HCID 21896895, compoundHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 178467023HCID 178467023, compound

Procedure

5-(4-Chloro-phenyl)-2-(2-ethoxy-4-methoxy-phenyl)-4-(3-methyl-butyl)-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-5-methyl-hexane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 401.1994, calculated for C23H30N2O2Cl [(M+H)+]401.1991.

Sources & evidence

ORD record
ord-88f0e694f13f4d1088d0786b7328fd4d
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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