HCID 21896882, compound → HCID 178467021, compound

HRID 719137Notes

Reaction equation

HRID 719137 reaction equation
ClC1C=CC(C(N)C(N)CC)=CC=1.Cl.C(OC1C=C(OC)C=CC=1C(=N)OCC)C.[Cl:31][C:32]1[CH:37]=[CH:36][C:35]([CH:38]2[NH:42][C:41]([C:43]3[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][C:44]=3[O:51][CH2:52][CH3:53])=[N:40][CH:39]2[CH2:54][CH:55]2CCCC2)=[CH:34][CH:33]=1>>[Cl:31][C:32]1[CH:33]=[CH:34][C:35]([CH:38]2[NH:42][C:41]([C:43]3[CH:48]=[CH:47][C:46]([O:49][CH3:50])=[CH:45][C:44]=3[O:51][CH2:52][CH3:53])=[N:40][CH:39]2[CH2:54][CH3:55])=[CH:36][CH:37]=1

Participants

4

Reactant 3

HCID 21896882HCID 21896882, compoundHCID 21896884HCID 21896884, compoundHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 178467021HCID 178467021, compound

Procedure

5-(4-Chloro-phenyl)-2-(2-ethoxy-4-methoxy-phenyl)-4-ethyl-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-butane-1,2-diamine and ethyl 2-ethoxy-4-methoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 359.1524, calculated for C20H24N2O2Cl [(M+H)+]359.1521.

Sources & evidence

ORD record
ord-517137e1e4a84f83bb958e3a657d9f4c
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

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