HCID 21896896, compound → HCID 178466128, compound

HRID 719138Notes

Reaction equation

HRID 719138 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([NH2:17])[CH:9]([NH2:16])[CH2:10][CH:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:4][CH:3]=1.Cl.[CH2:19]([O:21][C:22]1[CH:32]=[C:31]([O:33][CH2:34][CH3:35])[CH:30]=[CH:29][C:23]=1[C:24](=N)OCC)[CH3:20].ClC1C=CC(C2NC(C3C=CC(OC)=CC=3OCC)=NC2CC2CCCC2)=CC=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[NH:17][C:24]([C:23]3[CH:29]=[CH:30][C:31]([O:33][CH2:34][CH3:35])=[CH:32][C:22]=3[O:21][CH2:19][CH3:20])=[N:16][CH:9]2[CH2:10][CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15]2)=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 21896896HCID 21896896, compoundHCID 21896897Ethyl 2,4-diethoxy-benzimidate hydrochlorideHCID 1784670165-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole

Product 1

HCID 178466128HCID 178466128, compound

Procedure

5-(4-Chloro-phenyl)-4-cyclopentylmethyl-2-(2,4-diethoxy-phenyl)-4,5-dihydro-1H-imidazole was prepared from 1-(4-chloro-phenyl)-3-cyclopentyl-propane-1,2-diamine and ethyl 2,4-diethoxy-benzimidate hydrochloride in an analogous manner as described for the preparation of 5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole (Example 9). HR-MS (ES, m/z) observed 427.2152, calculated for C25H32N2O2Cl [(M+H)+]427.2147.

Sources & evidence

ORD record
ord-fdd07d44714846548deb6afa03783a85
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

Loading…