[5-(4-Chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone → HCID 11455269, compound

HRID 719151Notes

Reaction equation

HRID 719151 reaction equation
F[C:2](F)(F)[C:3]([OH:5])=O.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]2[NH:19][C:18]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=3[O:28][CH2:29][CH3:30])=[N:17][CH:16]2[CH:31]2[CH2:35][CH2:34][CH2:33][CH2:32]2)=[CH:11][CH:10]=1.ClC1C=CC([CH:43]2[N:47]([C:48](N3CCN(C)CC3)=[O:49])C(C3C=CC(OC)=CC=3OCC)=[N:45][CH:44]2CC2CCCC2)=CC=1>>[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([CH:15]2[N:19]([C:48]([N:47]3[CH2:43][CH2:44][NH:45][C:3](=[O:5])[CH2:2]3)=[O:49])[C:18]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][C:21]=3[O:28][CH2:29][CH3:30])=[N:17][CH:16]2[CH:31]2[CH2:35][CH2:34][CH2:33][CH2:32]2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 11193096[5-(4-Chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanoneHCID 178467014HCID 178467014, compound

Product 1

HCID 11455269HCID 11455269, compound

Procedure

4-[5-(4-Chloro-phenyl)-4-cyclopentyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one was prepared from 5-(4-chloro-phenyl)-4-cyclopentyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-1H-imidazole, trifluoroacetate salt (Example 19) in an analogous manner as described for the preparation of [5-(4-chloro-phenyl)-4-cyclopentylmethyl-2-(2-ethoxy-4-methoxy-phenyl)-4,5-dihydro-imidazol-1-yl]-(4-methyl-piperazin-1-yl)-methanone (Example 24). HR-MS (ES, m/z) observed 525.2271, calculated for C28H34N4O4Cl [(M+H)+]525.2263.

Sources & evidence

ORD record
ord-efb7ee650b9e4e4f80e1ba9275a17028
Source dataset
uspto-grants-2006_11
Patent number
US07132421B2

Reaction notes

Loading…