Sodium methanethiolate → HCID 10936102, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 4-fluoro-benzo[a]phenazine-11-carboxylic acid (II.3, see Reference Example 1B (58 mg) in dry DMSO (3 mL) was added sodium thiomethoxide (55 mg) and the reaction mixture heated at 100° C. for 1.5 hours and 130° C. for 1 hour. The reaction mixture was then cooled to room temperature, quenched with acetic acid, extracted with ethyl acetate, washed with water, dried and the solvent removed in vacuo to yield the title compound as a red solid (37 mg).

Provenance & Evidence