反应详情

温度

110 °C

A mixture of 4-methoxy-benzo[a]phenazine-11-carboxylic acid methyl ester (IV.1) (350 mg) and 1-dimethylamino-2-propylamine (2 mL)(commercially available) was heated to 110° C. under N2 for 4 hours. The reaction mixture was then cooled and the excess amine was removed in vacuo. The residue was then purified using flash chromatography (silica, ethyl acetate and then 25% methanol in ethyl acetate) to yield the title compound as a yellow solid (164 mg).

1. temperatureThe reaction mixture was then cooled
2. customthe excess amine was removed in vacuo
3. customThe residue was then purified