Ammonium Chloride → HCID 10109109, compound

Participants

Reaction Steps

A mixture of 4-nitro-benzo[a]phenazine-11-carboxylic acid (2-dimethylamino-ethyl)-amide (176 mg), indium (154 mg) and saturated ammonium chloride solution (5 mL) in ethanol (20 mL) was heated to reflux for 3 hours. The reaction mixture was cooled, quenched with water and then filtered through celite. The filtrate was concentrated in vacuo, and the residue was treated with sodium bicarbonate solution, extracted into chloroform, dried (MgSO4) and the solvent removed in vacuo to yield the title compound as a red solid (163 mg) 3-Amino-benzo[a]phenazine-11-carboxylic acid (2-dimethylamino-ethyl)-amide was prepared in an analogous manner from 3-nitro-benzo[a]phenazine-11-carboxylic acid (2-dimethylamino-ethyl)-amide.

Provenance & Evidence