Tert-butyl 2-(2-azidoethoxy)ethyl(methyl)carbamate → tert-butyl N-(2-(2-aminoethoxy)ethyl)-N-methylcarbamate

Participants

Reaction Steps

A solution of tert-butyl 2-(2-azidoethoxy)ethyl(methyl)carbamate (41.9 g, 170 mmol) in 600 mL of MeOH was treated with 2.5 g of 10% Pd on carbon and shaken under H2 (3 Kg/cm2) for 24 h. The solution was then filtered through a Celite pad and concentrated to give 37.2 g of crude tert-butyl 2-(2-aminoethoxy)ethyl(methyl)carbamate as a light yellow liquid.

Provenance & Evidence