Hydrazine → HCID 178489097, compound

HRID 719263Notes

Reaction equation

HRID 719263 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11](=O)[C:12](=[N:16][OH:17])[C:13](=O)[CH3:14])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[NH2:19][NH2:20].C(=O)([O-])[O-:22].[Na+].[Na+]>C(O)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:20][N:19]=[C:13]([CH3:14])[C:12]=2[N+:16]([O-:17])=[O:22])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

5

Reactant 3

HCID 9321HydrazineHCID 10340Sodium CarbonateHCID 178491501HCID 178491501, compound

Product 1

HCID 178489097HCID 178489097, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
60 °C

Procedure

6.77 g of 1-(3,4-dimethoxyphenyl)butane-1,2,3-trione 2-oxime (42) were dissolved in 54 ml of acetic acid, after which 0.96 g of hydrazine was added dropwise at RT and the mixture was subsequently stirred at 60° C. for 2 h. Ice was added to the reaction solution, which was then neutralized with sodium carbonate and extracted with MTB-ether. The organic phase was dried over magnesium sulfate and subjected to rotary evaporation. The following was obtained: 43. C12H13N3O3 (247.26); MS (ESI) 248 (M+H)

Workup

  1. additionIce was added to the reaction solution, which
  2. extractionextracted with MTB-ether
  3. dry with materialThe organic phase was dried over magnesium sulfate
  4. customsubjected to rotary evaporation
  5. customThe following was obtained

Sources & evidence

ORD record
ord-f391485ab0644372ac7fd93d0faea97b
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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