HCID 178489097, compound → HCID 178489090, compound

HRID 719264Notes

Reaction equation

HRID 719264 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:15][N:14]=[C:13]([CH3:16])[C:12]=2[N+:17]([O-])=O)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]>C(O)C.[Pd]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:15][N:14]=[C:13]([CH3:16])[C:12]=2[NH2:17])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

4

Reactant 1

HCID 178489097HCID 178489097, compound

Product 1

HCID 178489090HCID 178489090, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

4.84 g of 5-(3,4-dimethoxyphenyl)-3-methyl-4-nitro-1H-pyrazole (43) were dissolved in 80 ml of ethanol, and 0.5 g of Pd/C was added to this solution. The solution was shaken under hydrogen for 2 h, then filtered through magnesium sulfate and subjected to rotary evaporation. The residue was chromatographed through silica gel (ethyl acetate/heptane 3/1). The following was obtained: 44 C12H15N3O2 (233.27); MS (ESI) 234 (M+H)

Workup

  1. filtrationfiltered through magnesium sulfate
  2. customsubjected to rotary evaporation
  3. customThe residue was chromatographed through silica gel (ethyl acetate/heptane 3/1)
  4. customThe following was obtained

Sources & evidence

ORD record
ord-fdd304dbb7b64d4c8508bdbcd8173dff
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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