Nicotinoyl chloride → HCID 178489095, compound

HRID 719270Notes

Reaction equation

HRID 719270 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:15][N:14]=[C:13]([CH3:16])[C:12]=2[NH2:17])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[C:18](Cl)(=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]2[NH:15][N:14]=[C:13]([CH3:16])[C:12]=2[NH:17][C:18](=[O:25])[C:19]2[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]

Participants

3

Reactant 2

HCID 82604Nicotinoyl chlorideHCID 178489090HCID 178489090, compound

Product 1

HCID 178489095HCID 178489095, compound

Procedure

The preparation took place in analogy with Example 15a), starting with 200 mg of 5-(3,4-dimethoxyphenyl)-3-methyl-1H-pyrazol-4-ylamine (44) and 168 mg of nicotinoyl chloride*HCl. The following was obtained: 57.

Workup

  1. customThe following was obtained

Sources & evidence

ORD record
ord-b414b3b21b22429b8fabfa9eaa8c1950
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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