反应详情

To a RT solution of 416 mg of 3-methyl-5-phenyl-1H-pyrazol-4-ylamine in 4.6 mL pyridine was added 242 μL of methoxyacetyl chloride. After 2 h at RT, the reaction mixture was concentrated under reduced pressure and the residue was dissolved in chloroform and washed with 0.5 N hydrochloric acid and saturated aqueous sodium carbonate and brine. The organic portion was dried with sodium sulfate and concentrated under reduced pressure. The residue contained the title compound as a tan, amorphous solid and was used without further purification.

1. concentrationthe reaction mixture was concentrated under reduced pressure
2. dissolutionthe residue was dissolved in chloroform
3. washwashed with 0.5 N hydrochloric acid and saturated aqueous sodium carbonate and brine
4. dry with materialThe organic portion was dried with sodium sulfate
5. concentrationconcentrated under reduced pressure
6. customwas used without further purification