4-(Trifluoromethyl)benzoyl chloride → HCID 178434575, compound

HRID 719292Notes

Reaction equation

HRID 719292 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7](Cl)=[O:8])=[CH:5][CH:4]=1.[CH3:14][C:15]1[C:19]([NH2:20])=[C:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[NH:17][N:16]=1>N1C=CC=CC=1>[CH3:14][C:15]1[C:19]([NH:20][C:7](=[O:8])[C:6]2[CH:10]=[CH:11][C:3]([C:2]([F:13])([F:12])[F:1])=[CH:4][CH:5]=2)=[C:18]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)[NH:17][N:16]=1

Participants

4

Reactant 2

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 178434570HCID 178434570, compound

Product 1

HCID 178434575HCID 178434575, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

361 mg of 4-trifluoromethylbenzoyl chloride were added dropwise to a solution of 300 mg of 3-methyl-5-phenyl-1H-pyrazol-4-ylamine in 5 ml of pyridine at room temperature. The reaction mixture was stirred for 16 h and then concentrated. The residue was extracted into dichloromethane and washed with 0.5M hydrochloric acid, at which point the title compound precipitated.

Workup

  1. concentrationconcentrated
  2. extractionThe residue was extracted into dichloromethane
  3. washwashed with 0.5M hydrochloric acid, at which
  4. customprecipitated

Sources & evidence

ORD record
ord-cf8051b980f94494972f1f3294eb6cab
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

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