HCID 178526319, compound → HCID 178507812, compound

HRID 719293Notes

Reaction equation

HRID 719293 reaction equation
[N:1]([C:3]1[C:4]([C:14]([F:17])([F:16])[F:15])=[N:5][NH:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=O>C(O)C.[Pd]>[NH2:1][C:3]1[C:4]([C:14]([F:17])([F:16])[F:15])=[N:5][NH:6][C:7]=1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

4

Reactant 1

HCID 178526319HCID 178526319, compound

Product 1

HCID 178507812HCID 178507812, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 6.6 g of 4-nitroso-5-phenyl-3-trifluoromethyl-1H-pyrazole (prepared as in Saloutin et al, J. Flourine Chem, vol 84, pp 107–111) in 200 mL ethanol was treated with 2.0 g 10% palladium/carbon catalyst and hydrogenated at RT and 50 psi for 7.5 hours. The reaction mixture was filtered through celite and washed well with ethanol. The filtrate was concentrated to give the title compound as a yellow solid.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. washwashed well with ethanol
  3. concentrationThe filtrate was concentrated

Sources & evidence

ORD record
ord-ed1643f5a2494095879ce84bc8e0619f
Source dataset
uspto-grants-2006_11
Patent number
US07132428B2

Reaction notes

Loading…