HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylate → Ethyl 2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-4-phenyl-1,3-thiazole-5-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylate | HCID 73239 | — |
| Reactant | 3-Chloro-2-methylbenzenesulfonyl chloride | HCID 522734 | — |
| Product | Ethyl 2-{[(3-chloro-2-methylphenyl)sulfonyl]amino}-4-phenyl-1,3-thiazole-5-carboxylate | HCID 10296783 | — |
Reaction Steps
The title compound was prepared from ethyl 2-amino-4-phenylthiazole-5-carboxylate and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (47.2 mg) with purity >90%. LCMS (pos) m/z 437.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07132436B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-f04e5b317b8542bcb00d57dc2f94a6e8 |
| Source note | uspto-grants-2006_11 |