4-N-Propylbenzenesulphonyl chloride → HCID 10157222, compound

HRID 719308Notes

Reaction equation

HRID 719308 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([NH2:13])[S:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[F:14].[CH2:15]([C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1)[CH2:16][CH3:17]>>[F:14][C:3]1[CH:4]=[CH:5][C:6]([C:8]2[N:12]=[C:11]([NH:13][S:24]([C:21]3[CH:22]=[CH:23][C:18]([CH2:15][CH2:16][CH3:17])=[CH:19][CH:20]=3)(=[O:26])=[O:25])[S:10][CH:9]=2)=[CH:7][C:2]=1[CH3:1]

Participants

3

Reactant 2

HCID 27372224-N-Propylbenzenesulphonyl chlorideHCID 27564332-amino-4-(4-fluoro-3-methylphenyl)-1,3-thiazole

Product 1

HCID 10157222HCID 10157222, compound

Procedure

The title compound was prepared from 2-amino-4-(4′-fluoro-3′-methyl)phenylthiazole and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (31.5 m) with puriy >90%. MS (pos) m/z 391.2.

Workup

  1. customto give a white solid (31.5 m) with puriy >90%

Sources & evidence

ORD record
ord-452489facd674c379ea4c64c1a532949
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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