3-Chloro-2-methylbenzenesulfonyl chloride → HCID 10111387, compound

HRID 719312Notes

Reaction equation

HRID 719312 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([NH2:13])[S:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[F:14].[Cl:15][C:16]1[C:17]([CH3:26])=[C:18]([S:22](Cl)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1>>[Cl:15][C:16]1[C:17]([CH3:26])=[C:18]([S:22]([NH:13][C:11]2[S:10][CH:9]=[C:8]([C:6]3[CH:5]=[CH:4][C:3]([F:14])=[C:2]([CH3:1])[CH:7]=3)[N:12]=2)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 27564332-amino-4-(4-fluoro-3-methylphenyl)-1,3-thiazole

Product 1

HCID 10111387HCID 10111387, compound

Procedure

The title compound was prepared from 2-amino-4-(4′-fluoro-3′-methyl)phenylthiazole and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (39.7 mg) with purity >90%. MS (pos) m/z 397.1.

Sources & evidence

ORD record
ord-224990ad03814ee083b68cf46ae562b3
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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