(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 10273930, compound

HRID 719315Notes

Reaction equation

HRID 719315 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]2[N:12]=[C:11]([NH2:13])[S:10][CH:9]=2)[CH:5]=[CH:4][C:3]=1[F:14].[C:15]1([C:21]2[CH:26]=[CH:25][C:24]([S:27](Cl)(=[O:29])=[O:28])=[CH:23][CH:22]=2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[F:14][C:3]1[CH:4]=[CH:5][C:6]([C:8]2[N:12]=[C:11]([NH:13][S:27]([C:24]3[CH:23]=[CH:22][C:21]([C:15]4[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=4)=[CH:26][CH:25]=3)(=[O:29])=[O:28])[S:10][CH:9]=2)=[CH:7][C:2]=1[CH3:1]

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 27564332-amino-4-(4-fluoro-3-methylphenyl)-1,3-thiazole

Product 1

HCID 10273930HCID 10273930, compound

Procedure

The title compound was prepared from 2-amino-4-(4′-fluoro-3′-methyl)phenylthiazole and 4-phenylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (15.8 mg) with purity >90%. MS (pos) m/z 425.2.

Sources & evidence

ORD record
ord-8f2b2360b05842d28a762e66ded8d07f
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

Loading…