2-Amino-4-(3-nitrophenyl)thiazole → HCID 10203866, compound

HRID 719316Notes

Reaction equation

HRID 719316 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:6]=1.[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25](Cl)(=[O:27])=[O:26]>>[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25]([NH:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:6]=1)(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 6135042-Amino-4-(3-nitrophenyl)thiazoleHCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chloride

Product 1

HCID 10203866HCID 10203866, compound

Procedure

The title compound was prepared from 2-amino-4-(-3-nitrophenyl)thiazole and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (27.3 mg) with purity >90%. MS (pos) m/z 444.0, 446.0.

Sources & evidence

ORD record
ord-3cbb8cfd634342b9b7a8b6874946606d
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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