4-(3-Pyridinyl)-2-thiazolamine → 4-Propyl-N-[4-(3-pyridinyl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 719320Notes

Reaction equation

HRID 719320 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:8]=[C:9]([NH2:12])[S:10][CH:11]=2)[CH:2]=1.[CH2:13]([C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1)[CH2:14][CH3:15]>>[CH2:13]([C:16]1[CH:21]=[CH:20][C:19]([S:22]([NH:12][C:9]2[S:10][CH:11]=[C:7]([C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[N:8]=2)(=[O:24])=[O:23])=[CH:18][CH:17]=1)[CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 1548934-(3-Pyridinyl)-2-thiazolamineHCID 27372224-N-Propylbenzenesulphonyl chloride

Product 1

HCID 99250184-Propyl-N-[4-(3-pyridinyl)-1,3-thiazol-2-yl]benzenesulfonamide

Procedure

The title compound was prepared from 4-(3-pyridyl)-1,3-thiazol-2-amine and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (2.3 mg) with purity >90%. MS (pos) m/z 360.2.

Sources & evidence

ORD record
ord-913149c9fd54454e98dbf5dc912344c2
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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