4-(5-Chlorothiophen-2-yl)-1,3-thiazol-2-amine → HCID 10111504, compound

HRID 719321Notes

Reaction equation

HRID 719321 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8]=[C:9]([NH2:12])[S:10][CH:11]=2)=[CH:4][CH:3]=1.[CH2:13]([C:16]1[CH:21]=[CH:20][C:19]([S:22](Cl)(=[O:24])=[O:23])=[CH:18][CH:17]=1)[CH2:14][CH3:15]>>[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8]=[C:9]([NH:12][S:22]([C:19]3[CH:20]=[CH:21][C:16]([CH2:13][CH2:14][CH3:15])=[CH:17][CH:18]=3)(=[O:24])=[O:23])[S:10][CH:11]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7017824-(5-Chlorothiophen-2-yl)-1,3-thiazol-2-amineHCID 27372224-N-Propylbenzenesulphonyl chloride

Product 1

HCID 10111504HCID 10111504, compound

Procedure

The title compound was prepared from 4-(5-chloro-2-thienyl)-1,3-thiazol-2-amine and 4-n-propylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a brown solid (16.4 mg) with purity >80%. MS (pos) m/z 399.2.

Sources & evidence

ORD record
ord-067a16e53fba4e94b082f795b0a84e45
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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