2,4,6-Trichlorobenzenesulfonyl chloride → HCID 10183009, compound

HRID 719330Notes

Reaction equation

HRID 719330 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8]=[C:9]([NH2:12])[S:10][CH:11]=2)=[CH:4][CH:3]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([Cl:21])[C:15]=1[S:22]([NH:12][C:9]1[S:10][CH:11]=[C:7]([C:5]2[S:6][C:2]([Cl:1])=[CH:3][CH:4]=2)[N:8]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 5213352,4,6-Trichlorobenzenesulfonyl chlorideHCID 7017824-(5-Chlorothiophen-2-yl)-1,3-thiazol-2-amine

Product 1

HCID 10183009HCID 10183009, compound

Procedure

The title compound was prepared from 4-(5-chloro-2-thienyl)-1,3-thiazol-2-amine and 2,4,6-trichlorobenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (24.0 mg) with purity >90%. MS (pos) m/z 461.0, 463.0.

Sources & evidence

ORD record
ord-98e2b9ea70524a048269f628cf0cef41
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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