(1,1'-Biphenyl)-4-sulphonyl chloride → N-(7-methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)[1,1'-biphenyl]-4-sulfonamide

HRID 719334노트

반응식

HRID 719334 반응식
Br.[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:15](=[CH:16][CH:17]=1)[C:10]1[N:11]=[C:12]([NH2:14])[S:13][C:9]=1[CH2:8][CH2:7]2.[C:18]1([C:24]2[CH:29]=[CH:28][C:27]([S:30](Cl)(=[O:32])=[O:31])=[CH:26][CH:25]=2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>>[CH3:2][O:3][C:4]1[CH:5]=[C:6]2[C:15](=[CH:16][CH:17]=1)[C:10]1[N:11]=[C:12]([NH:14][S:30]([C:27]3[CH:26]=[CH:25][C:24]([C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)=[CH:29][CH:28]=3)(=[O:32])=[O:31])[S:13][C:9]=1[CH2:8][CH2:7]2

참가 물질

3

반응물 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 28074737-Methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-amine hydrobromide

생성물 1

HCID 10138677N-(7-methoxy-4,5-dihydronaphtho[1,2-d][1,3]thiazol-2-yl)[1,1'-biphenyl]-4-sulfonamide

실험 절차

The title compound was prepared from 7-methoxy4,5-dihydronaphto[1,2-D][1,3]thiazol-2-amine hydrobromide and 4-phenylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white-yellow solid (17.0 mg) with purity >80%. MS (pos) m/z 449.2.

출처 및 근거

ORD 기록
ord-ee1c8a6d80554088b635cb35964a69c2
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07132436B2

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