(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 10224784, compound

HRID 719335Notes

Reaction equation

HRID 719335 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8]=[C:9]([NH2:12])[S:10][CH:11]=2)=[CH:4][CH:3]=1.[C:13]1([C:19]2[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[Cl:1][C:2]1[S:6][C:5]([C:7]2[N:8]=[C:9]([NH:12][S:25]([C:22]3[CH:21]=[CH:20][C:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[CH:24][CH:23]=3)(=[O:27])=[O:26])[S:10][CH:11]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 7017824-(5-Chlorothiophen-2-yl)-1,3-thiazol-2-amine

Product 1

HCID 10224784HCID 10224784, compound

Procedure

The title compound was prepared from 4-(5-chloro-2-thieny)-1,3-thiazol-2-amine and 4-phenylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (4.3 mg) with purity >80%. MS (pos) m/z 433.1, 435.1.

Sources & evidence

ORD record
ord-3e3d78ec14fe4b29a07c4d236c185704
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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