4-(3-Pyridinyl)-2-thiazolamine → 2,4-Dichloro-6-methyl-N-[4-(3-pyridinyl)-1,3-thiazol-2-yl]benzenesulfonamide

HRID 719337Notes

Reaction equation

HRID 719337 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[N:8]=[C:9]([NH2:12])[S:10][CH:11]=2)[CH:2]=1.[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22](Cl)(=[O:24])=[O:23]>>[Cl:13][C:14]1[CH:19]=[C:18]([Cl:20])[CH:17]=[C:16]([CH3:21])[C:15]=1[S:22]([NH:12][C:9]1[S:10][CH:11]=[C:7]([C:3]2[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=2)[N:8]=1)(=[O:24])=[O:23]

Participants

3

Reactant 2

HCID 1548934-(3-Pyridinyl)-2-thiazolamineHCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chloride

Product 1

HCID 102009742,4-Dichloro-6-methyl-N-[4-(3-pyridinyl)-1,3-thiazol-2-yl]benzenesulfonamide

Procedure

The title compound was prepared from 4-(3-pyridyl)-1,3-thiazol-2-amine and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (17.6 mg) with purity >90%. MS (pos) m/z 400.0,402.0.

Sources & evidence

ORD record
ord-5030df7c0378465dbf3265184de56912
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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