2,4-Dichloro-6-methylbenzenesulfonyl chloride → 2,4-Dichloro-N-[4-(2,5-dimethyl-3-furyl)-1,3-thiazol-2-yl]-6-methylbenzenesulfonamide

HRID 719341Notes

Reaction equation

HRID 719341 reaction equation
[CH3:1][C:2]1[O:3][C:4]([CH3:13])=[CH:5][C:6]=1[C:7]1[N:8]=[C:9]([NH2:12])[S:10][CH:11]=1.[Cl:14][C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([CH3:22])[C:16]=1[S:23](Cl)(=[O:25])=[O:24]>>[Cl:14][C:15]1[CH:20]=[C:19]([Cl:21])[CH:18]=[C:17]([CH3:22])[C:16]=1[S:23]([NH:12][C:9]1[S:10][CH:11]=[C:7]([C:6]2[CH:5]=[C:4]([CH3:13])[O:3][C:2]=2[CH3:1])[N:8]=1)(=[O:25])=[O:24]

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 21898208HCID 21898208, compound

Product 1

HCID 102236902,4-Dichloro-N-[4-(2,5-dimethyl-3-furyl)-1,3-thiazol-2-yl]-6-methylbenzenesulfonamide

Procedure

The title compound was prepared from 4-(2,5-dimethyl-3-furyl)-1,3-thiazol-2-ylamine (METHOD I) and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a yellow solid (11.6 mg) with purity >90%. MS (pos) m/z 417.1, 419.1.

Sources & evidence

ORD record
ord-2795d6c8e0944e2fa988db118a38b317
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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