2,4-Dichloro-6-methylbenzenesulfonyl chloride → HCID 10115153, compound

HRID 719342Notes

Reaction equation

HRID 719342 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10]2[N:11]=[C:12]([NH2:15])[S:13][CH:14]=2)=[CH:2]1.[Cl:16][C:17]1[CH:22]=[C:21]([Cl:23])[CH:20]=[C:19]([CH3:24])[C:18]=1[S:25](Cl)(=[O:27])=[O:26]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([C:10]2[N:11]=[C:12]([NH:15][S:25]([C:18]3[C:19]([CH3:24])=[CH:20][C:21]([Cl:23])=[CH:22][C:17]=3[Cl:16])(=[O:27])=[O:26])[S:13][CH:14]=2)=[CH:2]1

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 2826288HCID 2826288, compound

Product 1

HCID 10115153HCID 10115153, compound

Procedure

The title compound was prepared from 4-(1-benzothien-3-yl)-1,3-thiazol-2-amine (METHOD I) and 2,4-dichloro-6-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (47.0 mg) with purity >90%. MS (pos) m/z 455.0, 457.0.

Sources & evidence

ORD record
ord-3e3aec4f351b43fe89eeee021add3566
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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