2-Amino-4-(4-methoxyphenyl)thiazole → HCID 10135285, compound

HRID 719348Notes

Reaction equation

HRID 719348 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([NH2:14])[S:12][CH:13]=2)=[CH:5][CH:4]=1.[Cl:15][C:16]1[C:17]([CH3:26])=[C:18]([S:22](Cl)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1>>[Cl:15][C:16]1[C:17]([CH3:26])=[C:18]([S:22]([NH:14][C:11]2[S:12][CH:13]=[C:9]([C:6]3[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=3)[N:10]=2)(=[O:24])=[O:23])[CH:19]=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 1596442-Amino-4-(4-methoxyphenyl)thiazoleHCID 5227343-Chloro-2-methylbenzenesulfonyl chloride

Product 1

HCID 10135285HCID 10135285, compound

Procedure

The title compound was prepared from 4-(4-methoxy-phenyl)-thiazol-2-ylamine and 3-chloro-2-methylbenzenesulfonyl chloride as described in the synthetic METHOD B to give a white solid (58.0 mg) with purity >90%. MS (pos) m/z 395.2.

Sources & evidence

ORD record
ord-387af98c0a9040459edd1d15c5fab859
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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