HCID 615067, compound → HCID 10295066, compound

HRID 719363Notes

Reaction equation

HRID 719363 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[N:10]=[C:11]([NH2:14])[S:12][CH:13]=1.[CH2:15]([C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1)[CH2:16][CH3:17]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[C:9]1[N:10]=[C:11]([NH:14][S:24]([C:21]2[CH:22]=[CH:23][C:18]([CH2:15][CH2:16][CH3:17])=[CH:19][CH:20]=2)(=[O:26])=[O:25])[S:12][CH:13]=1

Participants

3

Reactant 2

HCID 615067HCID 615067, compoundHCID 27372224-N-Propylbenzenesulphonyl chloride

Product 1

HCID 10295066HCID 10295066, compound

Procedure

The title compound was prepared from 4-(2-chloro-6-fluorophenyl)-1,3-thiazol-2-amine (62 mg) and 4-n-propylbenzenesulfonyl chloride (59 mg) as descibed in the synthetic METHOD B to give a white solid (30.7 mg) with purity >90%: MS (pos) m/z 411.3, 413.3; MS (neg) m/z 409.5, 411.5.

Sources & evidence

ORD record
ord-d198a7b00acb4d39ba0ea023d2b3bf2c
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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