Benzenesulfonyl chloride → N-(4,5-Dihydrothieno[3,2-e][1,3]benzothiazol-2-yl)benzenesulfonamide

HRID 719368Notes

Reaction equation

HRID 719368 reaction equation
[N:1]1[C:5]2[C:6]3[CH:12]=[CH:11][S:10][C:7]=3[CH2:8][CH2:9][C:4]=2[S:3][C:2]=1[NH2:13].[C:14]1([S:20](Cl)(=[O:22])=[O:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[N:1]1[C:5]2[C:6]3[CH:12]=[CH:11][S:10][C:7]=3[CH2:8][CH2:9][C:4]=2[S:3][C:2]=1[NH:13][S:20]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)(=[O:22])=[O:21]

Participants

3

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 218981955,10-Dithia-3-azatricyclo[7.3.0.0,2,6]dodeca-1(9),2(6),3,11-tetraen-4-amine

Product 1

HCID 11439466N-(4,5-Dihydrothieno[3,2-e][1,3]benzothiazol-2-yl)benzenesulfonamide

Procedure

The title compound was prepared from 4,5-dihydrothieno[3,2-e][1,3]benzothiazol-2-amine (106 mg, synthesized according to METHOD I from 4-keto-4,5,6,7-tetrahydrothianaphthene) and benzenesulfonyl chloride (93 mg) as described in the synthetic METHOD A to give a white solid (13 mg) with a purity >90%: MS-ES (neg) m/z 347.2.

Sources & evidence

ORD record
ord-5de392f855a240aca25abb1caf675dfb
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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