2,4-Dichloro-6-methylbenzenesulfonyl chloride → HCID 21898215, compound

HRID 719373Notes

Reaction equation

HRID 719373 reaction equation
[Cl:1][C:2]1[S:3][C:4]([S:15]([CH3:18])(=[O:17])=[O:16])=[C:5]2[C:10]3[N:11]=[C:12]([NH2:14])[S:13][C:9]=3[CH2:8][CH2:7][C:6]=12.[Cl:19][C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[C:22]([CH3:27])[C:21]=1[S:28](Cl)(=[O:30])=[O:29]>>[Cl:19][C:20]1[CH:25]=[C:24]([Cl:26])[CH:23]=[C:22]([CH3:27])[C:21]=1[S:28]([NH:14][C:12]1[S:13][C:9]2[CH2:8][CH2:7][C:6]3=[C:2]([Cl:1])[S:3][C:4]([S:15]([CH3:18])(=[O:17])=[O:16])=[C:5]3[C:10]=2[N:11]=1)(=[O:30])=[O:29]

Participants

3

Reactant 2

HCID 28013872,4-Dichloro-6-methylbenzenesulfonyl chlorideHCID 21898198HCID 21898198, compound

Product 1

HCID 21898215HCID 21898215, compound

Procedure

The title compound was prepared from 6-chloro-8-(methylsulfonyl)-4,5-dihydrothieno[3,4-e][1,3]benzothiazol-2-amine (61 mg, synthesized according to METHOD I from 1-chloro-3-(methylsulfonyl)-4,5,6,7-tetrahydrobenzo-[c]thiophen-4-one) and 2,4-dichloro-6-methylbenzenesulfonyl chloride (54 mg) as described in the synthetic METHOD A to give a white solid (5.9 mg) with a purity >90%: MS-ES (pos) m/z 543.1.

Sources & evidence

ORD record
ord-f323d6ef35ed4331acb52be18bd7f6fb
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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