(1,1'-Biphenyl)-4-sulphonyl chloride → HCID 21898213, compound

HRID 719374Notes

Reaction equation

HRID 719374 reaction equation
[Cl:1][C:2]1[S:3][C:4]([S:15]([CH3:18])(=[O:17])=[O:16])=[C:5]2[C:10]3[N:11]=[C:12]([NH2:14])[S:13][C:9]=3[CH2:8][CH2:7][C:6]=12.[C:19]1([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:24]=[CH:23][C:22]([S:25](Cl)(=[O:27])=[O:26])=[CH:21][CH:20]=1>>[Cl:1][C:2]1[S:3][C:4]([S:15]([CH3:18])(=[O:17])=[O:16])=[C:5]2[C:10]3[N:11]=[C:12]([NH:14][S:25]([C:22]4[CH:21]=[CH:20][C:19]([C:29]5[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=5)=[CH:24][CH:23]=4)(=[O:27])=[O:26])[S:13][C:9]=3[CH2:8][CH2:7][C:6]=12

Participants

3

Reactant 2

HCID 74192(1,1'-Biphenyl)-4-sulphonyl chlorideHCID 21898198HCID 21898198, compound

Product 1

HCID 21898213HCID 21898213, compound

Procedure

The title compound was prepared from 6-chloro-8-(methylsulfonyl)4,5-dihydrothieno[3,4-e][1,3]benzothiazol-2-amine (61 mg, synesized according to METHOD I from 1-chloro-3-(methylsulfonyl)-4,5,6,7-tetrahydrobenzo-[c]thiophen-4-one) and 4-biphenylsulfonyl chloride (52 mg) as described in the synthetic METHOD A to give a beige solid (5.9 mg) with a purity >90%: MS-ES (neg) m/z 535.2.

Sources & evidence

ORD record
ord-a1b44311dee8444193dc0724abc99666
Source dataset
uspto-grants-2006_11
Patent number
US07132436B2

Reaction notes

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