HCID 69151089, compound → HCID 69151088, compound

HRID 719384Notes

Reaction equation

HRID 719384 reaction equation
C([O:8][N:9]1[C:13](=[O:14])[CH2:12][C@@H:11]([NH:15][S:16]([C:19]2[CH:24]=[CH:23][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:21][CH:20]=2)(=[O:18])=[O:17])[C:10]1=[O:31])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][N:9]1[C:13](=[O:14])[CH2:12][C@H:11]([NH:15][S:16]([C:19]2[CH:20]=[CH:21][C:22]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[CH:23][CH:24]=2)(=[O:18])=[O:17])[C:10]1=[O:31]

Participants

4

Reactant 1

HCID 69151089HCID 69151089, compound

Product 1

HCID 69151088HCID 69151088, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent2×

Procedure

N-[1-(benzyloxy)-2,5-dioxo-3-(R)-pyrrolidinyl][1,1′-biphenyl]4-sulfonamide was hydrogenated over 10% Pd on charcoal in ethanol+10% AcOH under normal atmospteric pressure in the standard hydrogenation apparatus and the reaction progress was monitored by TLC. Then,the catalysator was filtered,washed with ethanol and the title compound was purified by silica gel chromatography (EtOAc+10% MeOH+1% AcOH)

Workup

  1. customthe title compound was purified by silica gel chromatography (EtOAc+10% MeOH+1% AcOH)

Sources & evidence

ORD record
ord-5332ef95ec6440949673ed0597fe7013
Source dataset
uspto-grants-2006_11
Patent number
US07132434B2

Reaction notes

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