HCID 21898115, compound → HCID 58735392, compound

HRID 719385Notes

Reaction equation

HRID 719385 reaction equation
C([O:8][N:9]1[C:13](=[O:14])[CH2:12][CH:11]([NH:15][S:16]([N:19]2[CH2:24][CH2:23][CH:22]([C:25]3[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=3)[CH2:21][CH2:20]2)(=[O:18])=[O:17])[C:10]1=[O:32])C1C=CC=CC=1>C(O)C.[Pd]>[F:31][C:28]1[CH:29]=[CH:30][C:25]([CH:22]2[CH2:23][CH2:24][N:19]([S:16]([NH:15][C@H:11]3[CH2:12][C:13](=[O:14])[N:9]([OH:8])[C:10]3=[O:32])(=[O:17])=[O:18])[CH2:20][CH2:21]2)=[CH:26][CH:27]=1

Participants

4

Reactant 1

HCID 21898115HCID 21898115, compound

Product 1

HCID 58735392HCID 58735392, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

N-[1-(benzyloxy)-2,5-dioxo-3-pyrrolidinyl]4-(4fluorophenyl)-1-piperidinesulfonamide was hydrogenated over 10% Pd on charcoal in ethanol+10% AcOH under normal atmospteric pressure in the standard hydrogenation apparatus and the reaction progress was monitored by TLC. Then, the catalysator was filtered, washed with ethanol and the title compound was purified by silica gel chromatography (EtOAc+10% MeOH+1% AcOH).

Workup

  1. filtrationThen, the catalysator was filtered
  2. washwashed with ethanol
  3. customthe title compound was purified by silica gel chromatography (EtOAc+10% MeOH+1% AcOH)

Sources & evidence

ORD record
ord-fe3cd2314c594605b27b60b5f0286d3b
Source dataset
uspto-grants-2006_11
Patent number
US07132434B2

Reaction notes

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